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Stereoselective synthesis of optically active dihydrofurans and dihydropyrans via a ring closing metathesis reaction

✍ Scribed by Merve Çayir; Sema Demirci; Serdar Sezer; Cihangir Tanyeli


Book ID
113929511
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
552 KB
Volume
22
Category
Article
ISSN
0957-4166

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Total synthesis of octalactin A via ring
✍ Keith R Buszek; Nagaaki Sato; Youngmee Jeong 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 93 KB

A new total synthesis of the novel lactone natural product octalactin A is described. The key step involves the facile construction of the eight-membered lactone core via ring-closing metathesis (RCM). This oxocene was elaborated to give the powerful antitumor agent octalactin A.