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Synthesis of optically active 3-diazoacetylretinals with triisopropylphenylsulfonylhydrazone

✍ Scribed by Hyun Ok; Charles Caldwell; Daniel R. Schroeder; Anil K. Singh; Koji Nakanishi

Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
223 KB
Volume
29
Category
Article
ISSN
0040-4039

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✦ Synopsis

An improved synthesis of photoaffinity labeled, optically active retinal derivatives is presented. A stable, easy to handle. glyoxallc acid 2,4,6.-triisopropylphenylsulfonylhydrazone (TIPPS) reacts with 3hydroxyretinal to give the diazoacetylretinal analog in satisfactory yield.

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