The sequential Michael reaction of (S)-4,5-di-O-isopropylidenepent-2enoate la and lb with lithium enolate 2 afforded diastereo-and enantioselec--tively bicyclo[2.2.2]octane 2 and 6 (or 51, respectively. The adducts were efficiently converted into both enantiomeric keto aldehydes c-j-7 and (+)-I. Bic
β¦ LIBER β¦
Synthesis of optically active (+)-19-nortestosterone by asymmetric bis-annulation reaction
β Scribed by Isao Shimizu; Yoichiro Naito; Jiro Tsuji
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- French
- Weight
- 219 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0040-4039
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