## Abstract __N__‐protected peptides, which are important intermediates as a carboxyl component in the fragment condensation method, have been prepared in high yields by the reaction of __o__‐nitrophenylsulfenyl (Nps) __N__‐carboxy α‐amino acid anhydrides with unprotected peptides and amino acids i
Synthesis of O-(α-Glyco)peptides by the N-Iodosuccinimide Procedure
✍ Scribed by Prof. Dr. Horst Kessler; Dipl.-Chem. Matthias Kottenhahn; Dipl.-Chem. Andreas Kling; Dr. Cenek Kolar
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 347 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0044-8249
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📜 SIMILAR VOLUMES
An efficient procedure is described for the synthesis of N h -Fmoc-O-monobenzyl phosphonotyrosine from the corresponding dibenzyl derivative by monodebenzylation in the presence of sodium iodide. A simple work up procedure removes the by-products and the monobenzylated phosphono product is obtained
l?REVIOUSLY (1, 2) we have shown that N-oarboxy-a-amino acid anhydrides reaot with hydrooh+orides of amines to yield amino acid amides, aminohydroxemio acids and amidooxy-peptides. This reaotion was then applied to hydrochlorides of hydroxylamine and of N-alkyl and N,N-dialkyl