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Synthesis of novel spiro(indolone-3,2′-[1,3,4]thiadiazol)-2-ones and evaluation of their antidepressant and anticonvulsant activities

✍ Scribed by Alaa A. Hassan; Fathy F. Abdel-Latif; Ahmed M. Nour El-Din; Mohamed Abdel-Aziz; Sara M. Mostafa; Stefan Bräse

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
138 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

The reaction of 3‐(dicyanomethylene)‐2‐indolone in a solution of ethanol/piperidine with 4‐substituted thiosemicarbazides forms the derivatives of 5′‐(substituted amino)‐3′H–spiro(indoline‐3,2′‐[1,3,4]thiadiazol‐2‐one. Rationales for these conversions involving the nucleophilic addition on the dicyanomethylene carbon atom are presented. The prepared compounds were evaluated each for antidepressant activity using tail suspension behavioral despair test and anticonvulsant activity against pentylenetetrazol induced seizures in mice. J. Heterocyclic Chem., (2011).

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