## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a โFull Textโ option. The original article is trackable v
Synthesis of novel pyrazolopyrrolopyrazines, potential analogs of sildenafil
โ Scribed by Marina Kopp; Jean-Charles Lancelot; Patrick Dallemagne; Sylvain Rault
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2001
- Tongue
- English
- Weight
- 62 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0022-152X
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โฆ Synopsis
Abstract
Synthesis of novel pyrazolopyrrolopyrazines is herein described with the aim to reach new specific PDEโ5 inhibitors of potential clinical interest in male erectile dysfunction.
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A series of 8-aminoquinolines, analogous to primaquine and carrying a substituent in position two, have been synthesized by standard methods and tested for activity against Plas- modium berghei in mice. The results of preliminary biological tests are reported.
## Abstract magnified image Novel analogs of trifenagrel were synthesized by using inexpensive and reusable phosphotungstic acid, H~3~[PW~12~O~40~] (3 mol %) catalyst under classical heating. Two of the newly synthesized triaryl imidazoles exhibited moderate antibacterial activity. J. Heterocyclic