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Synthesis of novel (N-farnesyl) amino acids and their incorporation into peptides

✍ Scribed by BYK, GERARDO ;SCHERMAN, DANIEL


Book ID
115099914
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
659 KB
Volume
47
Category
Article
ISSN
0367-8377

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Synthesis of enantiopure azetidine 2-car
✍ FranΓ§ois Couty; Gwilherm Evano; Nicolas Rabasso πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 English βš– 231 KB

Enantiopure azetidine 2-carboxylic acids were prepared by hydrolysis of the corresponding 2-cyano azetidines, without ring cleavage of the azetidine or epimerization. The produced amino acids, which are conformationally constrained analogues of phenylalanine, can be cleanly debenzylated and used for