Building units for N-Backbone cyclic peptides. 2. Synthesis of protected N-(ω-thioalkylene) amino acids and their incorporation into dipeptide units
✍ Scribed by Gal Bilan; Chaim Gilon
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 636 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4020
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Backbone cyclization has become an important method for generating or stabilizing the bioactive conformation of peptides without affecting the amino acid side-chains. Up to now, backbone cyclic peptides were mostly synthesized with bridges between N-amino- and N-carboxy-functionalized peptide bonds.
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