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Building units for N-backbone cyclic peptides. 1. Synthesis of protected N-(.omega.-aminoalkylene)amino acids and their incorporation into dipeptide units

✍ Scribed by Byk, Gerardo; Gilon, Chaim


Book ID
127007052
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
683 KB
Volume
57
Category
Article
ISSN
0022-3263

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Backbone cyclization has become an important method for generating or stabilizing the bioactive conformation of peptides without affecting the amino acid side-chains. Up to now, backbone cyclic peptides were mostly synthesized with bridges between N-amino- and N-carboxy-functionalized peptide bonds.