Synthesis of novel isoquinolinone and 1,2-dihydroisoquinoline scaffolds via Ugi reaction and ring opening reaction of furans
✍ Scribed by Ji, Fei; Yi, Wen-bin; Sun, Mu; Lv, Mei-fang; Cai, Chun
- Book ID
- 120090730
- Publisher
- Springer
- Year
- 2013
- Tongue
- English
- Weight
- 504 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1381-1991
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## Abstract A four‐component reaction for the synthesis of 1,2‐dihydroisoquinoline derivatives is described. The __Huisgen__ 1,4‐dipolar intermediate, which is produced from isoquinoline and an electron‐deficient acetylene compound **1**, reacts with H~2~O in the presence of diketene to produce 1,2