ChemInform Abstract: Synthesis of 1,2-Dihydroquinolin-2-ylphosphonates and 1,2-Dihydroisoquinolin-1-ylphosphonates via Three-Component Reactions.
β Scribed by Ahmad Shaabani; Afshin Sarvary; Sajjad Mousavi-Faraz; Seik Weng Ng
- Book ID
- 115554223
- Publisher
- John Wiley and Sons
- Year
- 2012
- Weight
- 30 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0931-7597
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A tandem four-component reaction of 2-bromobenzaldehyde, alkyne, amine, and diethyl phosphite catalyzed by the combination of palladium and copper salts provides a facile and efficient route to 1,2-dihydroisoquinolin-1-ylphosphonate. A cascade Sonogashira-intramolecular cyclization-nucleophilic addi