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Multicatalytic synthesis of 1,2-dihydroisoquinolin-1-ylphosphonates via a tandem four-component reaction

โœ Scribed by Haibo Zhou; Hanpeng Jin; Shengqing Ye; Xiaodan He; Jie Wu

Book ID
104096652
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
352 KB
Volume
50
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A tandem four-component reaction of 2-bromobenzaldehyde, alkyne, amine, and diethyl phosphite catalyzed by the combination of palladium and copper salts provides a facile and efficient route to 1,2-dihydroisoquinolin-1-ylphosphonate. A cascade Sonogashira-intramolecular cyclization-nucleophilic addition may be involved in the reaction process.

๐Ÿ“œ SIMILAR VOLUMES

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## Abstract A fourโ€component reaction for the synthesis of 1,2โ€dihydroisoquinoline derivatives is described. The __Huisgen__ 1,4โ€dipolar intermediate, which is produced from isoquinoline and an electronโ€deficient acetylene compound **1**, reacts with H~2~O in the presence of diketene to produce 1,2