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Synthesis of novel halogenated cryptolepine analogues

✍ Scribed by Srinivas Reddy Gouni; S. Carrington; C. W. Wright

Publisher: Journal of Heterocyclic Chemistry
Year: 2006
Tongue: English
Weight: 104 KB
Volume: 43
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570430126

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✦ Synopsis

Abstract

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Cryptolepine (5‐N‐methyl‐10‐H‐indolo[3,2‐b]quinoline) is an indoloquinoline alkaloid present in the roots of Cryptolepis Sanguinolenta. In its hydrochloride form the alkaloid presents a number of bioactivities. The alkaloid also has cytotoxic properties that are likely to be due to its abilities to intercalate into DNA and inhibit the enzyme topoisomerase II, as well as the synthesis of DNA. In this research project five novel analogues of cryptolepine were chosen for synthesis.

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