## Abstract As part of an investigation directed to the search of new neurotropic agents we have prepared a number of hydroxy and hydroximino derivatives of the novel thieno and pyrazolo[2,1]benzothiazepine ring systems. Assignments of the __Z__ and __E__ hydroximino isomers were performed by study
The Synthesis of Hetero-Halogenated Derivatives of Phloroglucide Analogues[1]
✍ Scribed by Ali Akbar Moshfegh; Behnaz Mazandarani; Azarmidokht Nahid; Gholam Hosein Hakimelahi
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- German
- Weight
- 199 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A short synthesis of the title compounds is reported. Most of the compounds prepared were found to be active against a number of pathogenic microorganisms in vitro.
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## Abstract Esculetin (1) and the novel compounds 5‐chloroesculetin (5) and 5‐bromoesculetin (6) were obtained from a light‐induced cyclization of __trans__‐caffeic acid (3) catalyzed by [FeNa(edta)] and/or H~2~SO~4~, HCI, or HBr (__Scheme 1__). The experimental conditions for __trans__‐__cis__‐iso
## Abstract The synthesis of the title compounds is described. Some of the compounds prepared exhibited antimicrobial activity __in vitro.__ Structure‐activity relationship is briefly discussed.