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Synthesis of novel fused β-lactams by intramolecular 1,3-dipolar cycloadditions.51. Triazolocephems and triazolopenams

✍ Scribed by Clive L. Branch; Stephen C. Finch; Michael J. Pearson

Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
207 KB
Volume
23
Category
Article
ISSN
0040-4039

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✦ Synopsis

TriCyclic triazolocephem and triazolopenam csxboqlic acids have been synthesised, but only the former exhibited antibacterial activity.

Triazolocephems of type (1) have been shown

2 to possess a level of antibacterial activity that wss of sufficient interest for the investigation to be extended to the synthesis of related systems, in the hope of finding more potent derivatives. We now report the preparation of the isomeric system (2)3 and the triazolopenam (3).

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