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Synthesis of novel fused β-lactams by intramolecular 1,3-dipolar cycloadditions. 4. 17-phenoxyacetamido-8-oxo-1, 3-diazabicyclo [4.2.0] octane-2-carboxylic acids

✍ Scribed by Clive L. Branch; Michael J. Pearson

Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
185 KB
Volume
23
Category
Article
ISSN
0040-4039

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✦ Synopsis

octane-2-osrbowllc acrds have been synthesised and shown to possess weak antibaoterial activity.

We have recently desonbed2 the synthesis of the 8-oxo-l,j-drazabrcyclo [4.2.O] octane ring system. The 7-unsubstltuted free acids (l)3 were antibacterially inactrve, but it was surnusecl that a 7-aoylamrno group mght reprove the activity, s111ce the methyl ester (2) has been reported4 to possess weak sntimrcrobial actlvrty.

📜 SIMILAR VOLUMES

Synthesis of novel fused β-lactams by in
Synthesis of novel fused β-lactams by intramolecular 1,3-dipolar cycloadditions. 3.1 6-phenoxyacetamido-7-oxo-1,3-diazabicyclo[3.2.0]heptaine-2-carboxylic acids
✍ Michael J. Pearson 📂 Article 📅 1982 🏛 Elsevier Science 🌐 French ⚖ 179 KB

4-Metho~~bonylmete~~p~o~e~d~7~xo-l,3\_dia~bicyclo[3.2.0]heptane-2-oarboxylic acid and ~,7-dioxo-6-phenoqacetamido-l,~zab~cyclo[3.2.O]heptane-2-oarbozyl~c acid have been prepared. A recent codoation2from these laboratories described the total eynthesls of the 7-oxo-l,j-diazabicyclo[3.2.O]heptane rin