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Synthesis of novel fused β-lactams by intramolecular 1,3-dipolar cycloadditions. 3.1 6-phenoxyacetamido-7-oxo-1,3-diazabicyclo[3.2.0]heptaine-2-carboxylic acids

✍ Scribed by Michael J. Pearson

Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
179 KB
Volume
23
Category
Article
ISSN
0040-4039

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✦ Synopsis

4-Metho~~bonylmete~~p~o~e~d~7~xo-l,3_dia~bicyclo[3.2.0]heptane-2-oarboxylic acid and ~,7-dioxo-6-phenoqacetamido-l,~zab~cyclo[3.2.O]heptane-2-oarbozyl~c acid have been prepared.

A recent codoation2from these laboratories described the total eynthesls of the 7-oxo-l,j-diazabicyclo[3.2.O]heptane ring system. The derivatives (1) 3 and (2) were antlbacterially inactive, but it was hoped that the rncorporation of a crs acylamino side-&am rmght activate the S-la&am and improve aotivity.

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