Synthesis of novel acyclonucleosides. Reactions of 1-(2-oxopropyl)pyridazin-6-ones
✍ Scribed by Sam-Yong Choi; Sung Chul Shin; Yong-Jin Yoon
- Book ID
- 112129935
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1991
- Tongue
- English
- Weight
- 303 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0022-152X
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## Abstract Oxopropylation of 4,5‐dihalopyridazin‐6‐ones with chloroacetone afforded the corresponding 1‐(2‐oxo‐propyl) derivatives. Reaction of title compound with nucleophiles such as amines, alkoxides were investigated. In addition, selective reduction of 3‐nitro‐1‐(2‐oxopropyl)pyridazin‐6‐ones
## Ic lla-c la,b I, II a R'=H, R2=CN; b RI=H, R2=COOC2I-I~; c R l=Br, R2=4"BrCf;ILCO Compounds I cannot have the isomeric 6-aryl-4-hydroxypyridazine structure because the long-wavelength maximum (280-284 rim) corresponds to that of 3-carboxy-6-methyl-4-oxo-1-phenyl-1H-pyridazin-3-carboxylic acid (
## Abstract This paper presents the synthesis of 1‐[(pyrazol‐3‐yl)methyl]pyridazin‐6‐ones from ethyl 4‐(4,5‐dichloro‐6‐oxopyridazin‐1‐yl)‐3‐oxobutanoate.