Synthesis of 1-[(pyrazol-3-yl)methyl]pyridazin-6-ones
✍ Scribed by Hyun-A Chung; Young-Jin Kang; D. H. Kweon; Woo Song Lee; Yong-Jin Yoon
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2000
- Tongue
- English
- Weight
- 324 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
This paper presents the synthesis of 1‐[(pyrazol‐3‐yl)methyl]pyridazin‐6‐ones from ethyl 4‐(4,5‐dichloro‐6‐oxopyridazin‐1‐yl)‐3‐oxobutanoate.
📜 SIMILAR VOLUMES
This study of the title compound, C 14 H 9 F 3 N 4 O, is part of a series of structural investigations of cyclooxygenase-2 (COX-2) inhibitors containing 1,3-diarylpyrazole derivatives. The crystal structure is stabilized by intermolecular N-HÁ Á ÁO and C-HÁ Á ÁF hydrogen-bonding interactions.
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In the title compound, C 13 H 17 N 5 O 2 , the dihedral angle angle between the pyrazole and pyridazine rings is 14.44 (8) . The molecules are linked into a chain along the b axis by C-HÁ Á ÁO hydrogen bonds.