## Abstract This paper presents the synthesis of 1‐[(pyrazol‐3‐yl)methyl]pyridazin‐6‐ones from ethyl 4‐(4,5‐dichloro‐6‐oxopyridazin‐1‐yl)‐3‐oxobutanoate.
3,4,6-Tris(pyrazol-1-yl)pyridazine
✍ Scribed by Blake, Alexander J. ;Hubberstey, Peter ;Mackrell, Alexander D.
- Publisher
- International Union of Crystallography
- Year
- 2002
- Tongue
- English
- Weight
- 372 KB
- Volume
- 58
- Category
- Article
- ISSN
- 1600-5368
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📜 SIMILAR VOLUMES
This study of the title compound, C 14 H 9 F 3 N 4 O, is part of a series of structural investigations of cyclooxygenase-2 (COX-2) inhibitors containing 1,3-diarylpyrazole derivatives. The crystal structure is stabilized by intermolecular N-HÁ Á ÁO and C-HÁ Á ÁF hydrogen-bonding interactions.
In the title compound, C 13 H 17 N 5 O 2 , the dihedral angle angle between the pyrazole and pyridazine rings is 14.44 (8) . The molecules are linked into a chain along the b axis by C-HÁ Á ÁO hydrogen bonds.
## Abstract Condensation of 1‐arylhydrazono‐1‐benzotriazol‐1‐yl 2‐propanones (**5a‐c**) with DMF DMA afforded 1‐aryl‐3‐benzotriazol‐1‐yl‐1,4‐dihydropyridazine‐4‐ones (**8a‐c**). While condensation of 1‐functionally substituted methylbenzotriazoles **3b,c** with 2‐arylhydrazono‐3‐oxoarylpropanal **1