Synthesis and reactions of 1-(2-oxopropyl)pyridazin-6-ones

✍ Scribed by Woo-Yong Choi; Su-Dong Cho; Sung-Kyu Kim; Yong-Jin Yoon

• Book ID: 102338326
• Publisher: Journal of Heterocyclic Chemistry
• Year: 1997
• Tongue: English
• Weight: 420 KB
• Volume: 34
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570340436

✦ Synopsis

Abstract

Oxopropylation of 4,5‐dihalopyridazin‐6‐ones with chloroacetone afforded the corresponding 1‐(2‐oxo‐propyl) derivatives. Reaction of title compound with nucleophiles such as amines, alkoxides were investigated. In addition, selective reduction of 3‐nitro‐1‐(2‐oxopropyl)pyridazin‐6‐ones with iron/ammonium chloride in two phase solutions or zinc in acetic acid gave the corresponding 3‐amino or 3‐hydroxyimino derivatives.