Synthesis of Nonracemic Dimethyl α-(Hydroxyfarnesyl)phosphonates via Oxidation of Dimethyl Farnesylphosphonate with (Camphorsulfonyl)oxaziridines
✍ Scribed by Cermak, Diana M.; Du, Yanming; Wiemer, David F.
- Book ID
- 126029727
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 144 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
Reaction of phosphonate anions with enantiomerically pure (camphorsulfonyl)oxaziridines results in formation of nonracemic ot-hydroxy phosphonates. This enantioselective hydroxylation methodology provides convenient access to optically active ot-hydroxy phosphonates and their corresponding phosphoni
Enantioselective Synthesis of α-Hydroxy Phosphonates via Oxidation with (Camphorsulfonyl)oxaziridines. -Chiral dichloro oxaziridines (OXA) are used for the enantioselective introduction of the hydroxy group to prochiral phosphonates. The (+)-reagent favors the formation of (S)-products. Phosphonate