Synthesis of nonpolar peptide nucleic acid monomers containing fluoroaromatics
✍ Scribed by Shibata, Norio; Das, Biplab Kumar; Honjo, Hiroshi; Takeuchi, Yoshio
- Book ID
- 120428772
- Publisher
- Royal Society of Chemistry
- Year
- 2001
- Weight
- 177 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1472-7781
- DOI
- 10.1039/b103170h
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## Abstract All of the four nucleobases in DNA have replaced the 4‐hydroxy group of __N__‐[2‐(tert‐butoxycarbonylaminomethyl)‐trans‐4‐hydroxy] tetrahydropyrrole acetic acid methyl ester with __cis__ ‐stereochemistry. An efficient route for the synthesis of __N‐[2‐__(tert‐butoxycarbonylaminomethyl)‐
## Abstract magnified image New thymine peptide nucleic acid (PNA) monomer with glycylglycine backbone was prepared. This involved a key step of the coupling between iodinated serine (**3**) and 3‐benzoylthymine.