Synthesis of new peptide nucleic acid monomer with glycylglycine backbone
✍ Scribed by Tetsuo Yamasaki; Akiko Watanabe; Masanori Sakamoto; Masami Otsuka; Mohamed Abdel-Aziz; Takashi Iwashita
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2006
- Tongue
- English
- Weight
- 69 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
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New thymine peptide nucleic acid (PNA) monomer with glycylglycine backbone was prepared. This involved a key step of the coupling between iodinated serine (3) and 3‐benzoylthymine.
📜 SIMILAR VOLUMES
New PNA monomers containing aminoprolines or pyrrolidines as backbones have been synthesized. Oligomerisation was carried out on a solid support. Resistance to enzymatic degradation was tested.
## Abstract Four isomers of the monomer of peptide nucleic acid (PNA) were derived from (2__S__,4__R__)‐4‐hydroxyproline; they had different stereochemistries at the C^2^ and C^4^ positions in the pyrrolidine ring. These different backbone conformations corresponding to four different stereochemist
## Abstract All of the four nucleobases in DNA have replaced the 4‐hydroxy group of __N__‐[2‐(tert‐butoxycarbonylaminomethyl)‐trans‐4‐hydroxy] tetrahydropyrrole acetic acid methyl ester with __cis__ ‐stereochemistry. An efficient route for the synthesis of __N‐[2‐__(tert‐butoxycarbonylaminomethyl)‐