Synthesis of new building blocks for peptide nucleic acids containing monomers with variations in the backbone
β Scribed by Stephan Jordan; Christoph Schwemler; Winfried Kosch; Axel Kretschmer; Eckhardt Schwenner; Udo Stropp; Burkhard Mielke
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 263 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0960-894X
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β¦ Synopsis
New PNA monomers containing aminoprolines or pyrrolidines as backbones have been synthesized. Oligomerisation was carried out on a solid support. Resistance to enzymatic degradation was tested.
π SIMILAR VOLUMES
## Abstract magnified image New thymine peptide nucleic acid (PNA) monomer with glycylglycine backbone was prepared. This involved a key step of the coupling between iodinated serine (**3**) and 3βbenzoylthymine.
## Abstract __N__βBoc protected amino acids of analogues of peptide nucleic add (PNA.), which are a class of conformationally constrained building blocks based on 4βaminoproline backbone with chirality at 2βC and 4βC, have been synthesized. Those monomers can be used for the construction of novel p