Design and Synthesis of Novel Peptide Nucleic Acid Monomers

✍ Scribed by Jin-Quan Bai; Ying Li; Ke-Liang Liu

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 426 KB
• Volume: 19
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.20010190313

✦ Synopsis

Abstract

All of the four nucleobases in DNA have replaced the 4‐hydroxy group of N‐[2‐(tert‐butoxycarbonylaminomethyl)‐trans‐4‐hydroxy] tetrahydropyrrole acetic acid methyl ester with cis ‐stereochemistry. An efficient route for the synthesis of N‐[2‐(tert‐butoxycarbonylaminomethyl)‐trans‐4‐hydroxy]‐tetrahydropyrrole acetic acid methyl ester has been developed. Starting with this intermediate, the protected monomers were synthesized by the Mitsunobu reaction or via its tosylate.