Polycyclic aromatic hydrocarbons react at the K-region with N-bromoacetamide in acetic acid to provide trans-bromohydrin acetates which are readily cyclized to arene oxides. The simplicity of the approach makes radioactive and optically active K-region arene oxides easily available. K-Region arene
β¦ LIBER β¦
Synthesis of non-K-region arene oxides
β Scribed by Yagi, Haruhiko.; Jerina, Donald M.
- Book ID
- 126996030
- Publisher
- American Chemical Society
- Year
- 1973
- Tongue
- English
- Weight
- 298 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0002-7863
No coin nor oath required. For personal study only.
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A new general synthesis of arene oxides recently reported' from this laboratory has allowed the synthesis of the previously inaccessible "K-region" oxides (@, ,b) of the potent carcinogens '7,12-dimethylbenzraY anthracene ('7.1 P-DMBA) and benzola] pyrene2. This approach, however, still suffers from