Polycyclic aromatic hydrocarbons react at the K-region with N-bromoacetamide in acetic acid to provide trans-bromohydrin acetates which are readily cyclized to arene oxides. The simplicity of the approach makes radioactive and optically active K-region arene oxides easily available. K-Region arene
✦ LIBER ✦
Disubstituted “K-region” arene oxides
✍ Scribed by D. Avnir; A. Grauer; D. Dinur; J. Blum
- Book ID
- 103393156
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 403 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
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A new general synthesis of arene oxides recently reported' from this laboratory has allowed the synthesis of the previously inaccessible "K-region" oxides (@, ,b) of the potent carcinogens '7,12-dimethylbenzraY anthracene ('7.1 P-DMBA) and benzola] pyrene2. This approach, however, still suffers from