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Synthesis of “K-region” quinones and arene oxides of polycyclic aromatic hydrocarbons

✍ Scribed by Hee Cho; Ronald G. Harvey

Book ID
104244233
Publisher
Elsevier Science
Year
1974
Tongue
French
Weight
251 KB
Volume
15
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new general synthesis of arene oxides recently reported' from this laboratory has allowed the synthesis of the previously inaccessible "K-region" oxides (@, ,b) of the potent carcinogens '7,12-dimethylbenzraY anthracene ('7.1 P-DMBA) and benzola] pyrene2. This approach, however, still suffers from the limitation of requiring the use of osmium tetroxide in the initial step.

📜 SIMILAR VOLUMES

Facile synthesis of K-region arene oxide
Facile synthesis of K-region arene oxides
✍ P.J. van Bladeren; D.M. Jerina 📂 Article 📅 1983 🏛 Elsevier Science 🌐 French ⚖ 257 KB

Polycyclic aromatic hydrocarbons react at the K-region with N-bromoacetamide in acetic acid to provide trans-bromohydrin acetates which are readily cyclized to arene oxides. The simplicity of the approach makes radioactive and optically active K-region arene oxides easily available. K-Region arene