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Synthesis of non-bridging 18O3 labeled phosphate monoesters

✍ Scribed by Kim C. Calvo

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
199 KB
Volume
27
Category
Article
ISSN
0022-2135

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✦ Synopsis

A new method is reported for the synthesis of tri-'*O substituted osphate monoesters where the phosphoryl oxygen ester bond is

The method relies on the reactivity of trivaleni8phosphorus toward hydrolysis and oxidation to produce dimethyl [ 03]- phosphorochloridate with a minimal excess of labeled water. This chlorophosphate diester can be used to prepare a wide variety of phosphate monoesters where the three peripherial oxygens are labeled

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