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A convenient synthesis of carbon labeled adenine nucleotides: Adenosine-2-13C 5′ -phosphate

✍ Scribed by Rich B. Meyer Jr.; Corinne G. Wong

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
171 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Treatment of adenosine 5′‐phosphate 1‐oxide with base gave 5‐amino‐1‐β‐ D‐ribofuranosylimidazole‐4‐carboxamidoxime 5′‐ phosphate. Catalytic reduction of this amidoxime gave the versatile intermediate, 5‐amino‐1‐β‐D‐ribofuranosylimidazole‐ 4‐carboxamidine 5′‐phosphate. Condensation of this nucleo‐ tide with formaldehyde‐^13^C in the presence of palladium provided a simple preparation of adenosine‐2‐^13^C 5′‐phosphate.

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