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Synthesis of N,N′,N″-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor

✍ Scribed by Hyeung-geun Park; Mi-kyung Park; Ji-yeon Choi; Sea-hoon Choi; Jihye Lee; Boon-saeng Park; Myoung Goo Kim; Young-ger Suh; Hawon Cho; Uhtaek Oh; Jeewoo Lee; Hee-Doo Kim; Young-Ho Park; Hyun-Ju Koh; Kyung Min Lim; Joo-Hyun Moh; Sang-sup Jew


Book ID
108477399
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
134 KB
Volume
13
Category
Article
ISSN
0960-894X

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✍ Gottfried Heinisch; Barbara Matuszczak; Dietmar Rakowitz; Boonyong Tantisira 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 338 KB 👁 2 views

Starting from amino(di)azines and 2-chloro-6-methyliso(thio)cyanate a series of aryl-substituted urea and thiourea derivatives was prepared and screened as potential antiepileptics. Among the new derivatives tested, only 2b and 3c exhibited adequate anticonvulsant effects, whereas 3d and 4d were fou