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Synthesis of N,N′,N′′-Trisubstituted Thiourea Derivatives and Their Antagonist Effect on the Vanilloid Receptor.

✍ Scribed by Hyeung-geun Park; et al. et al.


Publisher
John Wiley and Sons
Year
2003
Weight
8 KB
Volume
34
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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Starting from amino(di)azines and 2-chloro-6-methyliso(thio)cyanate a series of aryl-substituted urea and thiourea derivatives was prepared and screened as potential antiepileptics. Among the new derivatives tested, only 2b and 3c exhibited adequate anticonvulsant effects, whereas 3d and 4d were fou