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Synthesis of nitrosourea derivatives of pyridine and piperidine as potential anticancer agents

โœ Scribed by Crider, A. Michael; Lamey, Randall; Floss, Heinz G.; Cassady, John M.; Bradner, William J.

Book ID
120090828
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
545 KB
Volume
23
Category
Article
ISSN
0022-2623

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The simple anthracycline analogues 3a-e were synthesized as potential anticancer agents. Anodic oxidation of the phenol derivative 4, phthalide anion annelation ofp-quinone monoacetals 5 and selective attachment of the side chain were the three key steps towards these target compounds.