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Synthesis of new pyrazolo[4,3-c]quinolin-3-one derivatives and some oxazolo[4,5-c]quinoline-2,4-diones

✍ Scribed by Lhassane Ismaïli; Bernard Refouvelet; Jean François Robert

Publisher
Journal of Heterocyclic Chemistry
Year
1999
Tongue
English
Weight
297 KB
Volume
36
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

The new pyrazolo[4,3‐c]quinolin‐3‐one derivatives 3a‐c and 6a‐c were prepared by the following three steps: first the preparation of ethyl 4‐hydroxyquinoline‐3‐carboxylate derivatives 1 and 4 by reaction of isatoic anhydrides and ethyl malonate and ethyl acetoacetate respectively, then chloration of 1 and 4 with phosphorus oxychloride to give 2 and 5 and finally the condensation of 2 and 5 with hydrazine and its derivatives. In addition, the successful synthesis of oxazolo[4,5‐c]quinoline‐2,4‐diones 9a‐f are reported.

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