✦ LIBER ✦

Tricyclic Heteroaromatic Systems. Pyrazolo[3,4-c]quinolin-4-ones and Pyrazolo[3,4-c]quinoline-1,4-diones: Synthesis and Benzodiazepine Receptor Activity

✍ Scribed by Daniela Catarzi; Vittoria Colotta; Flavia Varano; Lucia Cecchi; Guido Filacchioni; Alessandro Galli; Chiara Costagli

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 393 KB
Volume: 330
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.19973301205

No coin nor oath required. For personal study only.

✦ Synopsis

Some pyrazolo[3,4-c~quinoline-4-ones 1-14 and pyrazolo[3.4-c]quinoline-I ,4-diones 15-17 were prepared and biologically evaluated for their binding at the benzodiazepine receptor (BZR) in rat cortical membranes. The moderate binding activity of 1-5,7,9-10, 13 is attributable to the lack of the optional proton acceptor at position-1, while the inactivity of the 1,4-dione derivatives 15-17 is due to the lack of the essential proton acceptor at position-3. These conclusions confirm the validity of our proposed pharmacophoric model.

📜 SIMILAR VOLUMES

Synthesis and Antimicrobial Activity of

Synthesis and Antimicrobial Activity of Novel Pyrazolo[3,4-b]quinoline Derivatives

✍ Ola A. El-Sayed; Hassan Y. Aboul-Enein 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 61 KB 👁 1 views

Synthesis of Some Thiazole-, 1,3,4-Thiad

Synthesis of Some Thiazole-, 1,3,4-Thiadiazole-, and 4H-1,2,4-Triazole Derivatives of Pyrazolo[3,4-b]quinoline

✍ A. M. Farghaly; N. S. Habib; M. A. Khalil; O. A. El-Sayed 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 377 KB

Tricyclic Heteroaromatic Systems. 1,2,4-

Tricyclic Heteroaromatic Systems. 1,2,4-Triazolo[4,3-a]quinoxalines and 1,2,4-Triazino[4,3-a]quinoxalines: Synthesis and Central Benzodiazepine Receptor Activity

✍ Vittoria Colotta; Daniela Catarzi; Flavia Varano; Lucia Cecchi; Guido Filacchion 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 416 KB

## Abstract Some 1,2,4‐triazolo[4,3‐__a__]quinoxalines 1–10, and 1,2,4‐triazino[4,3‐__a__]quinoxalines 11–12 were prepared and biologically evaluated for their binding at the benzodiazepine receptor (BZR) in rat cortical membranes. The BZR affinity of 1–10 demonstrates that the presence of a proton

Synthesis of Pyrazolo[5,1–c][1,2,4]triaz

Synthesis of Pyrazolo[5,1–c][1,2,4]triazines, Isoxazolo[3,4-e]pyrazolo-[5,1–c][1,2,4]triazines and Aminopyridones

✍ Kamal U. Sadek; Nadia S. Ibrahim; Mohamed H. Elnagdi 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB 👁 1 views

Synthesis and Benzodiazepine Receptor Af

Synthesis and Benzodiazepine Receptor Affinity of Derivatives of the New Tricyclic Heteroaromatic System Pyrido[3′,2′:5,6]thiopyrano[4,3-c]pyridazin-3(2H,5H)-one

✍ Giampaolo Primofiore; Federico Da Settimo; Anna Maria Marini; Francesca Simorini 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 125 KB 👁 1 views

## Abstract Derivatives **7**–**13** of a new tricyclic heteroaromatic system, pyrido[3′,2′:5,6]thiopyrano[4,3‐__c__]pyridazin‐3(2__H__,5__H__)‐one, were prepared as potential ligands at the benzodiazepine receptor, in view of their structural analogy with potent ligands such as the pyrazoloquinoli

Nitriles in Heterocyclic Synthesis: Synt

Nitriles in Heterocyclic Synthesis: Synthesis of New Pyrazolo [1,5-a]pyrimidines, Pyrano[2,3-c]pyrazoles and Pyrano[3,4-c] pyrazoles

✍ Galal Eldin Hamza Elgemeie; Bahia Y. Riad; Galal A. Nawwar; Sherif Elgamal 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 285 KB 👁 2 views