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Synthesis of New Phospholipids Linked to Steroid-Hormone Derivatives Designed for Two-Dimensional Crystallization of Proteins

✍ Scribed by Luc Lebeau; Pierre Oudet; Charles Mioskowski

Publisher: John Wiley and Sons
Year: 1991
Tongue: German
Weight: 723 KB
Volume: 74
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19910740810

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✦ Synopsis

The synthesis of phospholipids 1n-3n, rationally designed for two-dimensional crystallization of progesterone and estrddiol receptors, is reported. The structure of these lipids provides them with essential properties such as fluidity and stability when spread into monolayers at the air/H20 interface, affinity for the protein to be crystallized, and accessibility of the ligand under the lipid monolayer.

') An additional problem encountered with steroid-hormone receptors related to the technique is the hydrophobicity of the ligands. These must be drawn far enough into the aqueous phase through the presencc of the highly hydrophilic spacer.

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