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Synthesis of a hemifluorinated amphiphile designed for self-assembly and two-dimensional crystallization of membrane protein

✍ Scribed by Julien Dauvergne; Ange Polidori; Catherine Vénien-Bryan; Bernard Pucci

Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
131 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

The work reported herein deals with the synthesis and the preliminary physical-chemical analysis of new hemifluorinated surfactant made up of one fluorinated chain linked to a tricarboxylic acid polar head which is able to complex a Ni atom and should favor the twodimensional crystallization of membrane proteins. Such a compound forms a Langmuir film which is a fluid at 20 °C and not perturbed by the presence of hydrocarbon detergent in aqueous solution.

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