Synthesis of New DNA Gyrase Inhibitors: Application of the DMSO Oxidation to the Conversion of the Amine into the Imine
β Scribed by Kondo, Hirosato; Taguchi, Masahiro; Sakamoto, Fumio; Tsukamoto, Goro; Jinbo, Yoshikazu
- Book ID
- 115481030
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 735 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
in recognition of his many seminal achievements in organic chemistry and his friendship over numerous years of Tetrahedron Board Meetings.
S-protected cysteine derivatives [Cys(Trt), Cys(MBzl), Cys(Dbs), Cys(Bzh)] as well as cysteine were converted to cystine by the action of DMSO / TFA; as examples, two model peptides, oxytocin and an ahuman calcitonin gene-related peptide ((r-hCGRP), were prepared by this reaction.
## Abstract The sequence converts 6βacylβcyclohexβ2βenones of type (I) directly to the required isoquinuclidinones.