Application of dimethylsulphoxide(DMSO) / trifluoroacetic acid(TFA) oxidation to the synthesis of cystine-containing peptide

✍ Scribed by Akira Otaka; Takaki Koide; Atsuko Shide; Nobutaka Fujii

• Book ID: 104225050
• Publisher: Elsevier Science
• Year: 1991
• Tongue: French
• Weight: 256 KB
• Volume: 32
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)92050-1

✦ Synopsis

S-protected cysteine derivatives [Cys(Trt), Cys(MBzl), Cys(Dbs), Cys(Bzh)] as well as cysteine were converted to cystine by the action of DMSO / TFA; as examples, two model peptides, oxytocin and an ahuman calcitonin gene-related peptide ((r-hCGRP), were prepared by this reaction.