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Synthesis of new chiral catalysts, N-alkyl-2-azanorbornyl-methanols, for the enantioselective addition of diethylzinc to arylaldehydes

✍ Scribed by Hiroto Nakano; Noriyuki Kumagai; Chizuko Kabuto; Hisao Matsuzaki; Hiroshi Hongo


Book ID
108036289
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
196 KB
Volume
6
Category
Article
ISSN
0957-4166

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New chiral catalysts for the highly enan
✍ Myung-Jong Jin; Sum-Jin Ahn; Kyoung-Soo Lee πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 French βš– 175 KB

Optically active amino thioacetate derivatives of (+l-norephedrine were found to act as effective catalysts for enantioselective addition of diethylzinc to aldehydes. This reaction provided optically active secondary alcohols with e.e. of up to >99%.