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New chiral catalysts for the highly enantioselective addition of diethylzinc to aldehydes

โœ Scribed by Myung-Jong Jin; Sum-Jin Ahn; Kyoung-Soo Lee

Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
175 KB
Volume
37
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Optically active amino thioacetate derivatives of (+l-norephedrine were found to act as effective catalysts for enantioselective addition of diethylzinc to aldehydes. This reaction provided optically active secondary alcohols with e.e. of up to >99%.

๐Ÿ“œ SIMILAR VOLUMES

Enantioselective diethylzinc addition to
Enantioselective diethylzinc addition to aldehydes using azetidine-derived chiral catalysts
โœ P.J Hermsen; J.G.O Cremers; L Thijs; B Zwanenburg ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 56 KB

High levels of enantioselectivity have been achieved in the diethylzinc addition to both aromatic and aliphatic aldehydes, employing readily available N-substituted-azetidinyl(diphenylmethyl)methanols as chiral catalysts.