New Chiral Pyrrolidine- and Pyrrolidinoneethanols for Enantioselective Addition of Diethylzinc to Arylaldehydes.
β Scribed by Yuko Okuyama; Hiroto Nakano; Mayumi Igarashi; Chizuko Kabuto; Hiroshi Hongo
- Book ID
- 101947937
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 95 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
Optically active amino thioacetate derivatives of (+l-norephedrine were found to act as effective catalysts for enantioselective addition of diethylzinc to aldehydes. This reaction provided optically active secondary alcohols with e.e. of up to >99%.
## Abstract The new chiral Ξ²βaminoalcohols of indolinylmethanols (__1__) and their reduced derivatives (__2__) were synthesized from (__S__)βindolineβ2βcarboxylic acid. Both (__R__) and (__S__) enantiomers of the optically active secondary alcohols have been successfully obtained in high enantiomer
Optically active ferrocenyl amino alcohols have been prepared from commercially available L-alaninol, L-leucinol and L-valinol. They have been utilized as chiral ligands in the catalytic addition of diethylzinc to aldehydes. The influence of the substituents on the stereogenic centers of the ligand