Synthesis of new 1-phenylthieno[1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one derivatives
✍ Scribed by Yang-Heon Song; Hoon Young Son
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2011
- Tongue
- English
- Weight
- 154 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-152X
- DOI
- 10.1002/jhet.549
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A series of novel 1‐phenylthieno[1,2,4]triazolo[4,3‐a]pyrimidin‐5(4__H__)‐one derivatives 5 and 6 were synthesized by oxidative cyclization of thienopyrimidinonyl hydrazones using iodobenzene diacetate. J. Heterocyclic Chem., (2011).
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## Abstract New functionalized 1,7‐diaryl‐6‐cyano‐1,2,4‐triazolo[4,3‐__a__]pyrimidin‐5(1__H__)‐one derivatives (**5a–j**) were synthesized via reaction of 5‐cyano‐6‐phenyl‐2‐thiouracil **1** with the respective hydrazonoyl halides **2a–j** and their biological activity was evaluated. The mechanism
## Abstract The 7‐chloro‐3‐(2‐chlorobenzyl)‐ and 7‐chloro‐3‐(2‐fluorobenzyl)‐1,2,3‐triazolo[4,5‐__d__]pyrimidines (**1** and **4**), by nucleophilic replacement with some hydrazides, gave the corresponding 7‐hydrazidoderivatives (**2a‐e** and **5a‐e**). These, by heating in Dowtherm, underwent an i