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Synthesis and antimicrobial activity of new functionalized derivatives of [1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-one

✍ Scribed by Ahmad S. Shawali; Asma M. Mahran; Afaf A. Nada

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
179 KB
Volume
18
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

New functionalized 1,7‐diaryl‐6‐cyano‐1,2,4‐triazolo[4,3‐a]pyrimidin‐5(1__H__)‐one derivatives (5a–j) were synthesized via reaction of 5‐cyano‐6‐phenyl‐2‐thiouracil 1 with the respective hydrazonoyl halides 2a–j and their biological activity was evaluated. The mechanism and the regioselectivity of the studied reactions are discussed. Β© 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:393–398, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20311

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✍ Yang-Heon Song; Hoon Young Son πŸ“‚ Article πŸ“… 2011 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 154 KB πŸ‘ 1 views

## Abstract A series of novel 1‐phenylthieno[1,2,4]triazolo[4,3‐__a__]pyrimidin‐5(4__H__)‐one derivatives **5** and **6** were synthesized by oxidative cyclization of thienopyrimidinonyl hydrazones using iodobenzene diacetate. J. Heterocyclic Chem., (2011).