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Synthesis of natural isocoumarins, artemidin and 3-propylisocoumarin

✍ Scribed by Batu, Gunes; Stevenson, Robert


Book ID
115511270
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
465 KB
Volume
45
Category
Article
ISSN
0022-3263

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Synthesis of isocoumarin-3-carboxylic ac
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## Abstract 2‐Carboxyphenylpyruvic acid and its derivatives with substituents in the phenyl nucleus can be prepared via a modified azlactone synthesis. These phenylpyruvic acids display a spontaneous ring closure into the corresponding isocoumarin carboxylic acids.

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## Abstract 3,5‐Dimethoxyhomophthalic acid was prepared efficiently in three steps, from 3,5‐dimethoxybenzyl bromide __via__ rhodium‐catalyzed direct carbonylation to 3,5‐dimethoxyphenylacetic acid followed by successive __o__‐formylation and oxidation. Isocoumarins related to agrimonolide and achl