Synthesis of Naphthoquinoles as Potential Antitumor Agents Related to Jacaranone
β Scribed by Deutsch, Howard M.; Zalkow, Leon H.
- Book ID
- 126787427
- Publisher
- American Chemical Society
- Year
- 1982
- Tongue
- English
- Weight
- 282 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0163-3864
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As a part of our continuing study of colchicinoids as therapeutically useful antitumor drugs, thiocolchicine derivatives, including their phosphate and other water soluble salts, were synthesized and evaluated for inhibition of tubulin polymerization and for in vitro cytotoxicity. Three compounds, 7
i l.bBenroquinones, 1.4-naphthoquinooes, as well as pyridines and quinolincs having 2-alkyloxsziridinyl substituents wcre synthcs i 7 d Thu nicthnd involves formation of aldimines and their oxidation to oxaziridincs. 1.4-Dimethoxyarenes bearing oxuiridinyl suhstiiuents were converted into the corres