✍ Scribed by Mlochowski, Jacek ;Kubicz, Elżbieta ;Kloc, Krystian ;Mordarski, Marian ;Peczyńska, Wanda ;Syper, Ludwik
No coin nor oath required. For personal study only.
i l.bBenroquinones, 1.4-naphthoquinooes, as well as pyridines and quinolincs having 2-alkyloxsziridinyl substituents wcre synthcs i 7 d Thu nicthnd involves formation of aldimines and their oxidation to oxaziridincs. 1.4-Dimethoxyarenes bearing oxuiridinyl suhstiiuents were converted into the corresponding quinones with silver(l1) dipicolinatc. Some or the oxaziridinylquinones and -;UIIICS exhibit activity against K B cells. and the structure-activity relationship is discussed in terms of the currunt theory of biolugically activated alkylating agents.
📜 SIMILAR VOLUMES
As a part of our continuing study of colchicinoids as therapeutically useful antitumor drugs, thiocolchicine derivatives, including their phosphate and other water soluble salts, were synthesized and evaluated for inhibition of tubulin polymerization and for in vitro cytotoxicity. Three compounds, 7