Pyroglutamic acid derivative (I) is proved to be an excellent chiral starting compound for the synthesis of title amino acids (IX), (X), and (V). The syntheses are based on a combination of methods previously used for the preparation of 4-and 5-substituted prolines. These methods are the ring openin
Synthesis of N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline (lisinopril)
✍ Scribed by M. T. Wu; A. W. Douglas; D. L. Ondeyka; L. G. Payne; T. J. Ikeler; H. Joshua; A. A. Patchett
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 291 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The preparation of SQ‐14225‐^14^C, anti‐hypertensive drug, is described. The starting material, methacrylic acid‐1‐^14^C, was prepared in a high yield by carbonation of the corresponding Grignard reagent with ^14^CO~2~. The final product was obtained from the acid through a four step sy
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A rapid, efficient method is described for the enzymatic conversion of S-adenosyl-L-[2(n)-3H]methionine to S-adenosyl-r-[2(n)-3H]homocysteine. Partially purified glycine N-methyltransferase is used in the reaction which yields 98% conversion. The product is purified using high-pressure liquid chroma
## Abstract The complex of N,N′‐bis‐1‐(carboxy‐2‐mercaptoethyl)ethylene‐diamine (EC) labelled with reduced Tc‐99m was proposed as a new agent in renal tubular secretion studies. Here we present the synthesis and single‐crystal X‐ray structure determination of the N,N′‐bis‐1‐(1‐carboxy‐2‐mercaptoeth