Synthesis of N-succinimidyl 4-[18F]fluorobenzoate, an agent for labeling proteins and peptides with 18F
✍ Scribed by Vaidyanathan, Ganesan; Zalutsky, Michael R
- Book ID
- 109945892
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 189 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1750-2799
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## Abstract We have labeled proinsulin connecting peptide (C‐peptide) with fluorine‐18 (__t__~½~=109.7 min) in order to perform __in vivo__ biodistribution and pharmacokinetic studies with position emission tomography (PET). This study reports the optimization of the conjugation labeling in the N‐t
## Abstract A fully automated synthesis of __N__‐succinimidyl 4‐[^18^F]fluorobenzoate ([^18^F]SFB) was carried out by a convenient three‐step, one‐pot procedure on the modified TRACERlab FX~FN~ synthesizer, including [^18^F]fluorination of ethyl 4‐(trimethylammonium triflate)benzoate as the precurs